2023 NCAA Women’s Sweet 16 Betting Odds and Predictions

On Friday, March 24, the NCAA Women’s Basketball Tournament Round of 16 will get under way. The first two rounds of tournament action have been thrilling with stellar on-court play and shocking upsets. There’s no reason to think that the Sweet 16 won’t continue the trend of compelling competition.

For the first time since 2007, the Stanford women’s basketball team will not be in the Sweet 16 after being bounced by the Ole Miss Rebels in the Round of 32¹. No. 1 seed, Indiana, also suffered a stunning upset before reaching the Sweet 16.

Despite some of the top seeds suffering defeats, the South Carolina Gamecocks are alive and well. They are heavily favored to win their Sweet 16 matchup and look unstoppable.

Check out the top March Madness betting sites for the latest Women’s Sweet 16 odds and place wagers on our predictions below.

NCAA Women’s Sweet 16 Schedule and How To Watch

The Sweet 16 of the NCAA Women’s Tournament follows a slightly different schedule than the NCAA Men’s Tournament. Where the men play the Sweet 16 on Thursday and Friday, the women play it on Friday and Saturday.

On Friday, March 24, the first four Sweet 16 matchups will get underway with a start time of 2:30 p.m. EST. All four games can be seen on ESPN.

On Saturday, March 25, four more matchups will be played to determine the Elite 8 showdowns for Sunday and Monday. Saturday’s first game tips-off at 11:30 a.m. EST with ESPN, ABC and ESPN2 broadcasting the day’s action².

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NCAAW Sweet 16 Odds

The following 2023 NCAAW Sweet 16 odds are courtesy of Bovada.

Greenville 1 Region Women’s Sweet 16 Matchups

UCLA Bruins (No. 4) vs. South Carolina Gamecocks (No. 1)

The South Carolina Gamecocks are four wins away from a perfect season. They would be the first team to go undefeated since the Baylor Bears in 2012.

South Carolina has been dominant through the Second Round. Norfolk State and South Florida didn’t stand a chance against the Gamecocks.

Despite a slow start and a 16-12 deficit entering the 2nd quarter, South Carolina blew out South Florida by a score of 76-45. Zia Cooke led the Gamecocks with 21 points in the winning effort³.

That was not their best performance and they still won by more than 30 points.

These Seniors are the Standard#MarchMadness x @GamecockWBB pic.twitter.com/veNvrZIlaZ

— NCAA March Madness (@MarchMadnessWBB) March 19, 2023

If the Gamecocks came out firing from the start, we are probably talking about a 40-point win. There aren’t any deficiencies for opponents to exploit on this roster and it shows in the box score.

Overall, South Carolina is second in points against and seventh in points conceded per game. According to the Simple Rating System, which evaluates the strength of schedule and point differential of teams, South Carolina leads the country in this metric⁴.

UCLA might make this game interesting for a quarter. However, South Carolina will be too much to handle. Expect Cooke and Aliyah Boston to continue their dominance as the Gamecocks pick up their 36th win of the season.

Bet on South Carolina to cover the spread as their moneyline of -5000 provides no value at the top college basketball betting sites.

Notre Dame Fighting Irish (No. 3) vs. Maryland Terrapins (No. 2)

Expect the Notre Dame Fighting Irish and Maryland Terrapins to play a tight game down to the final seconds in the Sweet 16. Notre Dame is coming off a hard-fought defensive win over the Mississippi State Bulldogs.

Neither team could get in a groove offensively in the Second Round. Much of it had to do with Notre Dame’s defense. The Fighting Irish locked down the Bulldogs for an abysmal 29.5% field goal percentage.

Mississippi State connected on just 3 of 20 attempts from 3-point land⁵. No one in the starting five for the Bulldogs scored more than 8 points⁶.

Maryland is capable of scoring, but they do not have a physical defense like the Fighting Irish. Overall this season, Notre Dame has conceded 58.4 points per game⁷, as opposed to 68.5 points allowed per game for the Terrapins⁸.

SWEET SIXTEEN, HERE COME THE IRISH!#GoIrish☘️ | #MarchMadness pic.twitter.com/NwcRzm4j1O

— Notre Dame WBB (@ndwbb) March 19, 2023

The Terrapins have the advantage offensively, but not by a large margin. Notre Dame’s defense is a tier-up from Maryland, though.

Maryland is 13th⁹ and Notre Dame is 9th¹⁰ in SRS this season. Notre Dame has a slight advantage in this matchup. The edge has to be with Notre Dame advancing to the Elite 8.

Take Notre Dame to pull off the upset.

Greenville 2 Region Women’s Sweet 16 Matchups

Miami Hurricanes (No. 9) vs. Villanova Wildcats (No. 4)

This is one of the unlikeliest matchups of the Sweet 16 as No. 9 seed Miami is still in the tournament following a 70-68 win over the No. 1 seeded Indiana Hoosiers.

Indiana was overrated going into the NCAAW Tournament as a No. 1 seed. That being said, it was nevertheless an impressive win for the Hurricanes. There were three separate Canes that scored at least 16 points¹¹.

Despite going 5-7 on the road, Miami has felt at home on a neutral court in the NCAAW Tournament. They have been clutch down the stretch, with a 62-61 win over Oklahoma State before edging out Indiana.

SWEET SIXTEEN BOUND 🙌 pic.twitter.com/O6p4VN35HZ

— Hurricanes Women’s Basketball (@CanesWBB) March 21, 2023

With an overall record of 21-12, Miami was not expected to reach the Sweet 16. They had a fine campaign, but no one had them going this far. Nevertheless, the Hurricanes still have long odds of winning the NCAA Tournament.

Villanova made easy work of the Florida Gulf Coast Eagles in the Second Round. The Wildcats had an early advantage and never gave up the lead for a wire-to-wire 76-57 victory.

Since mid-February, Villanova’s only loss was against UConn in the Big East Tournament. Otherwise, they’ve been in good shape against inferior opponents.

Miami has been impressive, but getting to the Elite 8 is going to be difficult. Look for the Wildcats to stop them from going any further in the NCAA Women’s Tournament.

LSU Tigers (No. 3) vs. Utah Utes (No. 2)

The LSU Tigers and Utah Utes is a must-watch showdown in the Sweet 16. Expect this matchup between the Tigers and Utes to be one of the most entertaining of the round.

LSU might be a No. 3 seed, but they could very well be a top seed in this tournament. The Tigers won their 31st game of the year with a 66-42 victory over a solid Michigan team in the Second Round.

Angel Reese had a monster performance to lead the Tigers into the Sweet 16. She scored 25 points and recorded a whopping 24 rebounds in the win¹².

LSU has an overall record of 31-2 going into the Sweet 16. They might not be perfect, but the Tigers were only two games off from going into this matchup against Utah at 33-0.

Angel Reese is the first player with 25 points, 20 rebounds and 5 blocks in a women’s NCAA tournament game since 2000 👏@LSUwbkb | #ThatsaW pic.twitter.com/KwNaa75C0p

— SportsCenter (@SportsCenter) March 20, 2023

Reese is going to be the best player on the floor in this matchup. This isn’t debatable. There is also an argument to be made that she is the most dominant player in the country.

The 6’3” forward has scored 23.8 points and a staggering 15.7 rebounds per game. She has helped lead LSU to 83.2 points per game for fifth in the NCAAW. Additionally, the Tigers are second in SRS¹³.

This one is going to be a battle between Reese and Alissa Pili, who has been a major contributor this season for Utah. She has recorded 21 points on 59.1% shooting and 5.6 rebounds per game¹⁴.

Utah averages 83.5 points per game, but the defense could tighten up. The Utes are third in scoring and 224th in points allowed per game. They are eighth with an SRS rating of 30.31¹⁵.

In an offensive shootout, look for LSU to ride the hot hand of Reese to the Elite 8.

Seattle 3 Region Women’s Sweet 16 Matchups

Tennessee Volunteers (No. 4) vs. Virginia Tech Hokies (No. 1)

The Tennessee Lady Vols put on a show in the Second Round against No. 12 Toledo. Behind a balanced attack from the starters and bench, Tennessee crushed Toledo for a 94-47 victory. This win followed a 93-50 drubbing of Saint Louis in the opening round.

The problem for Tennessee is that they are about to see a much bigger challenge than Saint Louis and Toledo in the Sweet 16. The Lady Vols go from the No. 13 and No. 12 seeds in the Seattle 3 Region to No. 1.

Virginia Tech brings a smothering defense with them to the Sweet 16. Following a 58-33 win in the First Round, the Hokies put the clamps on South Dakota State for a 72-60 victory.

This is one of the best defenses in women’s college basketball. The 29-4 Hokies are allowing 56.4 points per game, which is the 25th-best mark in the NCAAW. With 72.1 points scored per game, finding wins hasn’t been tough for Virginia Tech¹⁶. Overall, the Lady Vols are 235th in the NCAAW with 66.3 points allowed per game¹⁷.

Expect Tennessee to stay in this game with their scoring. However, Virginia Tech should come up with a clutch stop or two in the final minutes to preserve a victory.

Ohio State Buckeyes (No. 3) vs. Connecticut Huskies (No. 2)

The Ohio State Buckeyes march on following a close call against the North Carolina Tar Heels in the Second Round. On Monday night, the Buckeyes edged out the Tar Heels for a 71-69 win.

Ohio State received a complete performance from their starting five. Four players recorded at least 14 points, as everyone chipped in to beat the Tar Heels¹⁸.

Along with their win over North Carolina, the women defeated a No. 1 seed in the Big Ten Tournament. Before getting blown out by Iowa, Ohio State dispatched Indiana by a score of 79-75¹⁹.

The Buckeyes are a team that goes all-in with their offense. They have been in several high-scoring shootouts this season. Ohio State wins games, but this is not the most well-balanced group in women’s college basketball.

Aaliyah Edwards

AND-1 pic.twitter.com/VPGhj4wQ9h

— UConn Women’s Basketball (@UConnWBB) March 21, 2023

Despite being eighth with 80.7 points per game, Ohio State is 275th with 68.2 points allowed per game. They own an SRS rating of 26.69 for 15th in the NCAAW²⁰.

UConn is looking for their 12th NCAA Women’s Basketball National Championship on April 2²¹. They are the most accomplished women’s college basketball team over the last two decades and have a really good squad this season.

The Huskies are going into the Sweet 16 with a cumulative record of 31-5. On Monday, the lady Huskies cleared Baylor for a 77-58 win in the Round of 32.

They are third in the NCAAW with an SRS of 34.67. It doesn’t get much more balanced than this UConn squad in women’s college basketball. Back the Huskies in the Sweet 16 by double digits.

Seattle 4 Region Women’s Sweet 16 Matchups

Ole Miss Rebels (No. 8) vs. Louisville Cardinals (No. 5)

On Sunday, the Ole Miss Rebels shocked the No. 1 seed of the Seattle 4 Region in Stanford.

Cameron Brink missed the tournament opener with an illness²². She played against Ole Miss, but it could have contributed to Stanford being off. Regardless, credit Ole Miss for stepping up to defeat Stanford in a 54-49 final.

The key for the Rebels is avoiding a letdown against Louisville. Teams either use a big win as a confidence builder, or they crash out in their next outing. We will have to see how Ole Miss handles the stunning upset.

Overall, this season, Ole Miss is 21st in the country with 56.3 points allowed per game. They have one of the better defenses, which we saw on display against Stanford. However, the Rebels have been prone to going cold from the field.

Earned another opportunity 👊

The No. 5 Cards will take on No. 8 Ole Miss on Friday at 10 pm ET on ESPN#GoCards X #MarchMadness pic.twitter.com/AeQefi4eQt

— Louisville Women’s Basketball (@LouisvilleWBB) March 21, 2023

Louisville is coming off an impressive performance against Texas. In an all-around solid performance, the Cardinals pulled away for a 73-51 win. Hailey Van Lith had a big showing, as she scored 21 points for Louisville²³.

This should be a close contest between Ole Miss and Louisville. It may not be the most thrilling matchup, but a competitive game. Take the points in a contest that could come down to the final shot.

Colorado Buffaloes (No. 6) vs. Iowa Hawkeyes (No. 2)

There are many people that would argue Iowa Hawkeye guard, Caitlin Clark, is the best player in the NCAAW Tournament. The 21-year-old is scoring 26.8 points and averaging 7.3 rebounds per game this season²⁴.

She might be the best, but Clark needs more support if the Hawkeyes are going to win the NCAAW National Championship. The bench must step up and contribute.

Caitlin Clark went OFF for the Hawkeyes 😤 pic.twitter.com/lxwx4rOATP

— espnW (@espnW) March 20, 2023

Iowa’s reserves haven’t excelled when Clark needs a breather. In any event, Clark is fully capable of carrying Iowa over this Buffaloes squad.

The Hawkeyes lead the NCAAW with 87.4 points scored per game. There isn’t another women’s team in college basketball that can score like Iowa. They are sixth with a team SRS of 33.16²⁵.

Iowa’s defense is going to hurt them against superior teams later in the tournament. However, Clark and Iowa should put up big numbers on Colorado.