The opening 2023 NFL Week 4 odds are now live and ready to wager on at NFL betting sites. Sharp sports bettors use opening NFL odds to jump on soft lines and monitor how they shift throughout the week before kickoff.
We have everything that you need for the NFL Week 4 betting odds to help with your NFL betting strategy for the upcoming slate of matchups. This includes point spread betting, moneyline betting, and Over-Under betting wagers. Head below to check out our best NFL Week 4 predictions. NFL odds are courtesy of Bovada:
Detroit Lions vs. Green Bay Packers Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Detroit Lions | +1 (-110) | -105 | Over 46.5 (-110) |
| Green Bay Packers | -1 (-110) | -115 | Under 46.5 (-110) |
The Lions and Packers open the Week 4 card with an NFC North rivalry matchup at Lambeau Field. As you can see, it’s a tight one at sports betting sites.
Jordan Love and the Packers’ offense struggled without left tackle David Bakhtiari, despite completing a 17-point comeback. Christian Watson and Aaron Jones were also inactive for the Packers.
In Week 3, the Lions’ pass rush was all over Desmond Ridder and the Atlanta Falcons. If Aidan Hutchinson and the Lions have a repeat performance, it will be a long night for the Packers.
This is one of those games where you’ll have to closely monitor the injury report before kickoff. Both sides are dealing with injuries, and it’s too early to tell who is playing.
Currently, though, we expect the Lions’ defense to decide this matchup on Thursday Night Football.
Do your dance, Aidan Hutchinson 🕺
The Lions seal the game with a sack fumble recovery 🦁
📺: FOX pic.twitter.com/KRVmC20lRI
— FOX Sports: NFL (@NFLonFOX) September 24, 2023
Lions vs. Packers Prediction:
- Point Spread Bet: Detroit Lions +1 (-110)
- Moneyline Bet: Detroit Lions (-105)
- Over-Under Bet: Under 46.5 (-110)
Atlanta Falcons vs. Jacksonville Jaguars Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Atlanta Falcons | +3 (-110) | +145 | Over 45.5 (-110) |
| Jacksonville Jaguars | -3 (-110) | -165 | Under 45.5 (-110) |
The Falcons and Jaguars are coming off ugly performances. Both teams want to quickly delete Week 3 from their memories before flying overseas for the London game.
Ridder and the Falcons’ one-dimensional offense could not develop a rhythm. Ridder is a sitting duck in the pocket when the running game isn’t performing efficiently.
Fortunately, the running game should have success against the Jaguars’ defense. The offensive line should bounce back following an ugly performance in Detroit.
Consider taking the points in a matchup that should go down to the wire in the fourth quarter.
Falcons vs. Jaguars Prediction:
- Point Spread Bet: Atlanta Falcons +3 (-110)
- Moneyline Bet: Atlanta Falcons (+145)
- Over-Under Bet: Under 45.5 (-110)
Washington Commanders vs. Philadelphia Eagles Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Washington Commanders | +7 (-110) | +265 | Over 44.5 (-110) |
| Philadelphia Eagles | -7 (-110) | -345 | Under 44.5 (-110) |
Sam Howell’s confidence was rattled in a 37-3 loss against the Buffalo Bills last week. The Commanders had multiple chances in the red zone, including from the goal line when they were inches from cutting the lead to 10-7.
Unfortunately, Howell does not have a “get right” matchup in Week 4. The Commanders are on the road versus a tough Philadelphia Eagles’ secondary. After throwing four interceptions, Howell does not have it easy at Philadelphia.
Expect the Eagles to force Howell to throw into the teeth of their secondary. He will play better, but the Eagles likely pull away for a 10 to 14-point win at home.
What a play by @ajepenesa24 for the Pick-6 🔥 #BillsMafia
📺: #BUFvsWAS on CBS
📱: Stream on #NFLPlus https://t.co/UQdQ05hqXN pic.twitter.com/wjNlav5bTl— NFL (@NFL) September 24, 2023
Commanders vs. Eagles Prediction:
- Point Spread Bet: Philadelphia Eagles -7 (-110)
- Moneyline Bet: Philadelphia Eagles (-345)
- Over-Under Bet: Under 44.5 (-110)
Los Angeles Rams vs. Indianapolis Colts Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| LA Rams | -1.5 (-110) | -120 | Over 45.5 (-110) |
| Indianapolis Colts | +1.5 (-110) | +100 | Under 45.5 (-110) |
With rookie QB Anthony Richardson ruled out in Week 3 versus the Ravens, Gardner Minshew led the Colts to an improbable win as 8-point underdogs at Baltimore.
The Colts’ defense gets a huge pat on the back for holding Lamar Jackson and the Ravens to 19 points at home. They catch the Rams in a tough spot after an appearance on Monday Night Football at Cincinnati.
After flying home for a few days, the Rams will pack their bags back up for Indianapolis in Week 4. Following a confidence-building win over the Ravens, there is value in these NFL Week 4 odds on the Colts as a home underdog.
Rams vs. Colts Prediction:
- Point Spread Bet: Indianapolis Colts +1.5 (-110)
- Moneyline Bet: Indianapolis Colts (+100)
- Over-Under Bet: Under 45.5 (-110)
Baltimore Ravens vs. Cleveland Browns Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Baltimore Ravens | +1 (-110) | +100 | Over 44.5 (-110) |
| Cleveland Browns | -1 (-110) | -120 | Under 44.5 (-110) |
The Ravens are looking to recover after blowing a late lead against the Colts. It’s unlikely to get any easier at Cleveland Browns Stadium.
In their second game at home, the Browns dominated the Tennessee Titans in a 27-3 victory. In Week 1, the Browns’ defense held the Bengals to three points in a 24-3 victory.
The offseason signing of Za’Darius Smith has paid off in a big way for the Browns. Opposing offensive lines no longer have the ability of only preparing for Myles Garrett, who dominated on Sunday with 3.5 sacks.
Deshaun Watson doesn’t have an easy assignment versus the Ravens, but he has looked good at home. The Browns as a small favorite is a solid value bet at home in Week 4.
Ravens vs. Browns Prediction:
- Point Spread Bet: Cleveland Browns -1 (-110)
- Moneyline Bet: Cleveland Browns (-120)
- Over-Under Bet: Under 44.5 (-110)
Tampa Bay Buccaneers vs. New Orleans Saints Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Tampa Bay Buccaneers | +3 (-115) | +130 | Over 40.5 (-110) |
| New Orleans Saints | -3 (-105) | -155 | Under 40.5 (-110) |
The Buccaneers are heading into Week 4 on a short week following a marquee showdown against the Eagles on Monday Night Football.
Saints’ starting QB Derek Carr left Lambeau Field with a shoulder injury. It was serious enough that he went to the hospital for tests.
Jameis Winston was thrown into the game cold off the bench. He couldn’t prevent the Packers from pulling off a 17-point comeback and stealing a victory.
With a week to prepare for the Buccaneers, expect him to Winston to play better. Look for the Saints’ defense to propel New Orleans to a win and cover at home.
Buccaneers vs. Saints Prediction:
- Point Spread Bet: New Orleans Saints -3 (-105)
- Moneyline Bet: New Orleans Saints (-155)
- Over-Under Bet: Under 40.5 (-110)
Denver Broncos vs. Chicago Bears Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Denver Broncos | -2 (-110) | -135 | Over 44.5 (-110) |
| Chicago Bears | +2 (-110) | +115 | Under 44.5 (-110) |
In the ugliest matchup of the week, the winless Broncos head to Chicago for a meeting against the winless Bears.
The Broncos and Bears are coming off embarrassing performances. That is being generous.
Three weeks into the season, the Broncos and Bears appeared to quit on the field. Someone has to win this game, or at least tie at Soldier Field.
Russell Wilson hasn’t publicly criticized his coaching staff like the other side, so there’s that. We can envision the Bears getting booed off the field in this battle between early-season dumpster fires.
Broncos vs. Bears Prediction:
- Point Spread Bet: Denver Broncos -2 (-110)
- Moneyline Bet: Denver Broncos (-135)
- Over-Under Bet: Over 44.5 (-110)
Minnesota Vikings vs. Carolina Panthers Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Minnesota Vikings | -3 (-110) | -150 | Over 44.5 (-105) |
| Carolina Panthers | +3 (-110) | +130 | Under 44.5 (-115) |
The Vikings opened the season at 0-3 after a 28-24 loss to the Chargers at home. Minnesota had the ball in the red zone with seconds remaining, but Kirk Cousins threw a game-ending interception.
As we predicted, the Vikings were set to regress after winning the NFC North last year. There is a lot of football left, but something is missing from this group.
For one, the Vikings need help for Justin Jefferson, as the offensive game plan is far too one-dimensional without Dalvin Cook in the backfield.
The Panthers’ NFL Week 4 odds as a home underdog is an attractive value wager at football betting sites.
Vikings vs. Panthers Prediction:
- Point Spread Bet: Carolina Panthers +3 (-110)
- Moneyline Bet: Carolina Panthers (+130)
- Over-Under Bet: Under 44.5 (-115)
Pittsburgh Steelers vs. Houston Texans Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Pittsburgh Steelers | -4.5 (-110) | -210 | Over 40.5 (-110) |
| Houston Texans | +4.5 (-110) | +175 | Under 40.5 (-110) |
The Steelers travel to Houston for a Week 4 date with the hot Texans. Rookie QB C.J. Stroud is coming off a phenomenal performance against the Jacksonville Jaguars on the road.
Ohio State QBs have not had the most success in the NFL, but Stroud has been an outlier through the first three games of his NFL career.
Stroud and the Texans are playing with confidence going into Week 4. The key to this one is stopping T.J. Watt off the edge.
Watt will get his, but 4.5 is too many points to lay on the road here.
Rookie to rookie. @CJ7STROUD hits Tank Dell for a 68-yard TD!
📺: #HOUvsJAX on FOX
📱: Stream on #NFLPlus https://t.co/UQdQ05hqXN pic.twitter.com/NszwLZjorq— NFL (@NFL) September 24, 2023
Steelers vs. Texans Prediction:
- Point Spread Bet: Houston Texans +4.5 (-110)
- Moneyline Bet: Houston Texans (+175)
- Over-Under Bet: Over 40.5 (-110)
Cincinnati Bengals vs. Tennessee Titans Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Cincinnati Bengals | -1.5 (-110) | -120 | Over 44.5 (-110) |
| Tennessee Titans | +1.5 (-110) | +100 | Under 44.5 (-110) |
Joe Burrow’s status for Week 4 will have to be watched closely. Even if he starts at Tennessee, the Bengals’ QB does not have a clean bill of health.
At the time of this writing, Burrow is a game-time decision against the Rams on Monday Night Football. The opening NFL Week 4 odds afford the Bengals a slight advantage at -1.5.
The Titans were smacked by the Browns last week after defeating the Chargers in overtime a week earlier. It’s going to be that kind of season for the Titans.
One week they’ll look like a playoff team, and the next a Top 5 team in the 2024 NFL Draft. In Week 4, look for the Titans to handle a banged-up Bengals squad on a short week.
Bengals vs. Titans Prediction:
- Point Spread Bet: Tennessee Titans +1.5 (-110)
- Moneyline Bet: Tennessee Titans (+100)
- Over-Under Bet: Under 44.5 (-110)
Miami Dolphins vs. Buffalo Bills Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Miami Dolphins | +2.5 (-110) | +130 | Over 53 (-110) |
| Buffalo Bills | -2.5 (-110) | -150 | Under 53 (-110) |
The matchup of the week is the Miami Dolphins and Buffalo Bills in Orchard Park. The Dolphins are coming off a mesmerizing 70-20 win over the Broncos.
Meanwhile, the Bills throttled the Commanders on the road, 37-3. In a showdown of two teams planning on going to the conference championship game, we have to side with the better defense at home.
Josh Allen should put together a solid performance for the NFL awards in this one. Currently, Tua Tagovailoa is favored to win NFL MVP, but Allen will improve his odds in Week 4.
Dolphins vs. Bills Prediction:
- Point Spread Bet: Buffalo Bills -2.5 (-110)
- Moneyline Bet: Buffalo Bills (-150)
- Over-Under Bet: Over 53 (-110)
Las Vegas Raiders vs. Los Angeles Chargers Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Las Vegas Raiders | +4 (-110) | +175 | Over 49.5 (-110) |
| LA Chargers | -4 (-110) | -210 | Under 49.5 (-110) |
The Chargers were one play away from dropping to 0-3 on the season. Instead, it was the Vikings that lost and currently sport a winless record.
They are fortunate to have an opportunity to get to .500 against the Raiders in Week 4. The defense has been abysmal, as Justin Herbert is being forced to pass for big yardage every week.
The Raiders will complete some big plays on this defense. That said, the Chargers should have too much firepower for Jimmy Garoppolo and the Raiders.
The @Chargers secure the W with a goal line interception! #LACvsMIN pic.twitter.com/NPDc5LZBpJ
— NFL (@NFL) September 24, 2023
Raiders vs. Chargers Prediction:
- Point Spread Bet: LA Chargers -4 (-110)
- Moneyline Bet: LA Chargers (-210)
- Over-Under Bet: Over 49.5 (-110)
Arizona Cardinals vs. San Francisco 49ers Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Arizona Cardinals | +14 (-110) | +650 | Over 42 (-110) |
| San Francisco 49ers | -14 (-110) | -950 | Under 42 (-110) |
In the biggest upset of the early 2023 season, the Cardinals shocked the NFL with a 28-16 win over the Cowboys.
What happened to the Cowboys?
Simply put, they took the Cardinals lightly. Joshua Dobbs ran over one of the best defenses in the NFL.
This week, expect the 49ers’ defense to bring the Cardinals back down to earth. The Cardinals are in for a rude awakening against the well-rested 49ers in the Bay Area.
Cardinals vs. 49ers Prediction:
- Point Spread Bet: San Francisco 49ers -14 (-110)
- Moneyline Bet: San Francisco 49ers (-950)
- Over-Under Bet: Under 42 (-110)
New England Patriots vs. Dallas Cowboys
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| New England Patriots | +7 (-110) | +250 | Over 42.5 (-110) |
| Dallas Cowboys | -7 (-110) | -300 | Under 42.5 (-110) |
The Cardinals’ upset over the Cowboys was the worst-case scenario for the Patriots. The Patriots should expect to find an angry Cowboys squad at AT&T Stadium.
We like the Patriots’ defense, but Mac Jones needs to move the ball consistently. That will prove to be difficult against the Cowboys in Arlington.
The Cowboys are unlikely to run away in a blowout, but a 10-point win appears realistic.
Patriots vs. Cowboys Prediction:
- Point Spread Bet: Dallas Cowboys -7 (-110)
- Moneyline Bet: Dallas Cowboys (-300)
- Over-Under Bet: Under 42.5 (-110)
Kansas City Chiefs vs. New York Jets Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| KC Chiefs | -8.5 (-110) | -420 | Over 44.5 (-110) |
| NY Jets | +8.5 (-110) | +315 | Under 44.5 (-110) |
Patrick Mahomes and the Chiefs’ offense finally played like themselves in a 41-10 win over the Bears. It could have been much worse if not for Mahomes and the starters getting pulled.
Where do the Jets find offense against the Chiefs? Aaron Rodgers wants to return for the playoffs, but not at this rate with Zach Wilson at QB.
The Chiefs’ offensive playmakers are awake now. They should lead the Chiefs to a double-digit win on the road.
Andy Reid is a legend. @Chiefs pic.twitter.com/TsTuKk89Os
— NFL (@NFL) September 24, 2023
Chiefs vs. Jets Prediction:
- Point Spread Bet: Kansas City Chiefs -8.5 (-110)
- Moneyline Bet: Kansas City Chiefs (-420)
- Over-Under Bet: Under 44.5 (-110)
Seattle Seahawks vs. New York Giants Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Seattle Seahawks | -1.5 (-110) | -125 | Over 44.5 (-115) |
| NY Giants | +1.5 (-110) | +105 | Under 44.5 (-105) |
MetLife Stadium gets another primetime matchup in Week 4. The Giants host the Seahawks to close out this week’s action in New York.
Following a 30-12 loss to the 49ers, the Giants should appreciate the extra time to prepare for the Seahawks. They’ve only looked good for one half of football, after coming back to beat the Cardinals in Week 2.
Is this the week that the Giants put it all together? The Seahawks are confident after back-to-back wins, but look for the Giants to play desperate football in primetime to pick up a close win.
Seahawks vs. Giants Prediction:
- Point Spread Bet: New York Giants +1.5 (-110)
- Moneyline Bet: New York Giants (+105)
- Over-Under Bet: Over 44.5 (-115)
NFL Week 4 Best Bet
We don’t want to call it a must-win scenario, but the Chargers desperately needed to beat the Vikings to remain competitive in the AFC West.
After picking up their first win of the season, the Chargers are likely going to gain some confidence back at home this week. Kenneth Murray Jr.’s interception likely changed the whole dynamic of the season for this team.
After a physical Sunday Night Football matchup against the Steelers, expect the Raiders to be spent for the Chargers in Week 4. While the defense won’t be perfect, Herbert should thrive against the Raiders’ secondary.
Best NFL Week 4 Parlay
Parlay betting should not be your only strategy for betting on NFL football. That said, NFL parlays can be fun to play, and your best chance at hitting it big on a small wager.
For our best NFL Week 4 parlay, we are laying down $100 on a five-team moneyline parlay. This parlay has the potential for an impressive return to bettors:
- Dallas Cowboys (-300)
- Kansas City Chiefs (-420)
- San Francisco 49ers (-950)
- Buffalo Bills (-150)
- New York Giants (+105)
If all five teams win outright, you can win $523.24 on just a $100 wager. For the best NFL parlay odds and payouts in Week 4, Bovada is our online sportsbook of choice. For more Week 4 NFL predictions, check out our highly successful NFL A.I. Picks.
